Asymmetric Titanium-Catalyzed Cyclopropanation of Nitriles with Grignard Reagents
نویسندگان
چکیده
منابع مشابه
Iron-catalyzed alkylations of aromatic grignard reagents.
Significance: The development of iron-catalyzed cross-coupling reactions is an extremely promising field of research, taken into account the importance of this method for current organic synthesis and the multiple problems connected with commonly used Pdand Ni-catalyzed processes. The group of Cahiez reported the first iron-catalyzed alkyl–aryl cross-coupling reaction, suitable for industrial l...
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An efficient and highly enantioselective copper-catalyzed allylic alkylation of phosphonates and phosphine oxides with Grignard reagents and Taniaphos or phosphoramidites as chiral ligands is reported. Transformation of these products leads to a variety of new phosphorus-containing chiral intermediates.
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Phenyl- and ethyl-magnesium bromides undergo regioselective asymmetric allylic substitution with high enantioselectivity under the catalysis of chiral amidophosphane-copper(I) complexes.
متن کاملCopper-catalyzed asymmetric conjugate addition of Grignard reagents to cyclic enones.
It is no longer necessary to use dialkylzinc reagents to obtain enantioselectivities >95% in the copper-catalyzed asymmetric conjugate addition of organometallic compounds to cyclic enones. We now report how this can be accomplished by using inexpensive and readily available Grignard reagents. Screening of bidentate ligands provided outstanding results with copper complexes of commercially avai...
متن کاملCatalytic asymmetric conjugate addition of Grignard reagents to chromones.
A highly regio- and enantioselective copper catalysed direct conjugate addition of Grignard reagents to chromones has been developed taking advantage of the reduced reactivity of the resulting magnesium enolates. This methodology tolerates a broad scope of alkyl Grignards including secondary alkyl magnesium reagents as well as functionalised chromones.
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ژورنال
عنوان ژورنال: SynOpen
سال: 2018
ISSN: 2509-9396
DOI: 10.1055/s-0036-1591933